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项光亚

来源: 发布时间 2017-09-14 15:38:11 点击数:

项光亚,男,1968年生,湖北黄梅人,博士,教授,博士生导师,主要从事靶向药物传递系统和药物合成研究。主要讲授的课程包括《有机化学》、《生物偶联技术》、《药学文献检索与利用》等,曾多次荣获金沙赌城官方网站教学质量奖,荣获过2004年金沙赌城官方网站“三育人奖”、2011年金沙赌城官方网站第二届研究生导师“师表奖”、2016年获金沙赌城官方网站“优秀班主任”、2017年获金沙赌城官方网站“师德先进个人”等荣誉称号。近年来,参编的教材包括人民卫生出版社出版的有机化学(第七版和第八版副主编),有机化学学习指导(第三版,第四版)等以及中国医药科技出版社出版的《有机化学》(主编,2016年)《药学文献检索与利用》(第二版,副主编)等近十本教材。教学研究方面,曾主持过校级省级教学研究项目多项,获得过金沙赌城官方网站优秀教学成果奖二等奖一次(第二),一等奖一次(第一),此外还多次指导国家大学生创新科研训练计划项目,主持教育部“质量工程”药学国家特色专业建设以及参与建设生物药学创新人才培养试验区建设。科学研究方面,近年来先后主持了国家级、省部级科研项目十多项,发表论文六十余篇,其中在包括《Acta biomaterialia》、《Angew. Chem. Int. Ed》、《Nanomedicine: Nanotechnology, Biology, and Medicine》、《Theranostics》、《Molecular Therapy》、《Bioconjugate Chemistry》、《Journal of Pharmaceutical Sciences》、《International Journal of Pharmaceuticals》、《Journal of Drug Targeting》、《International Journal of Nanomedicine》、《European Journal of Medicinal Chemistry》等国际著名刊物发表的SCI收录论五十余篇。

研究方向:

1.纳米给药系统研究;

2.药物合成新技术;

3.纳米医学影像

承担的主要课题

1.国家自然科学基金“叶酸-酶偶联物的制备及生物活性和体内分布”(主持,2004-2006);30300430

2.国家自然科学基金:叶酸靶向荧光/磁共振多功能脂质体纳米探针的制备及性能研究(主持,2008-2010)30772669

3.教育部新世纪优秀人才支持计划“叶酸靶向脂质体的研究”(主持,2009-2011)

4.国家自然科学基金项目“针对肿瘤组织和肿瘤血管的多靶点阿霉素脂质体给药系统研究”(主持,2011-2013)81072596

5.国家自然科学基金项目,新型脂包被顺铂/磷酸钙Bmi1 siRNA纳米粒抑制肝癌干细胞并协同治疗肝癌的研究,国家自然科学基金(81673368,2017-2020)

6.国家自然科学基金项目,顺铂/过氧化钙纳米系统综合调控肿瘤微环境逆转肿瘤耐药的研究,国家自然科学基金(81973257,2020-2023)

近五年发表的论文列表:

◆Chen, Yan; Chen, Chen; Zhang, Xiaojuan; He, Chuanchuan; Zhao, Pengxuan; Li, Minsi; Fan, Ting; Yan, Ruicong; Lu, Yao; Lee, Robert J.; Khan, Muhammad Waseem; Sarfraz, Muhammad;Ma, Xiang*; Yang, Tan*; Xiang, Guangya*, Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects,Acta Pharmaceutica Sinica B, 2020,10(6):1106-1121

◆Chen, Yan ; Lu, Yao ;Lee, Robert J.;Xiang, Guangya*,Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications,International Journal of Nanomedicine,2020:15 3099-3120

◆Zhao, Pengxuan#; Hou, Xucheng#; Yan, Jingyue; Du, Shi; Xue, Yonger; Li, Wenqing;Xiang, Guangya*; Dong, Yizhou*,Long-term storage of lipid-like nanoparticles for mRNA delivery,Bioactive Materials,2020,5(2):358-363

◆Liu, Xiaoguang; Dong, Xiuxiu; He, Chuanchuan; Zhang, Xiaojuan;Xiang, Guangya*; Ma, Xiang*,New polyazamacrocyclic 3-hydroxy-4-pyridinone based ligands for iron depletion antitumor activity,Bioorganic chemistry,2020,96:103574

◆Zhang, Xiaojuan#; He, Chuanchuan#; Yan, Ruicong ; Chen, Yan ; Zhao, Pengxuan ; Li, Minsi; Fan, Ting ; Yang, Tan ;Lu, Yao ;Luo, Jun* ; Ma, Xiang* ; Xiang, Guangya*,HIF-1 dependent reversal of cisplatin resistance via anti-oxidative nano selenium for effective cancer therapy,Chemical Engineering Journal,2020,380: 122540

◆Zhang, Xiaojuan# ;He Chuanchuan#; Liu, Xiaoguang; Chen, Yan; Zhao, Pengxuan ; Chen, Chen; Yan, Ruicong; Li, Minsi; Fan, Ting; Altine, Bouhari; Yang, Tan; Lu, Yao ; Lee, Robert J. ;Gai, Yongkang*;Xiang, Guangya*,One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy,Theranostics,2020,10(7):2918-2929

◆Li, Minsi ; Zhao, Pengxuan; Fan, Ting; Chen, Yan; Zhang, Xiaojuan; He, Chuanchuan; Yang, Tan; Lee, Robert J.; Khan, Muhammad Waseem; Raza, Shahid Masood;Ma, Xiang*; Lu, Yao* ; Xiang, Guangya*,Biocompatible co-loading vehicles for delivering both nanoplatin cores and siRNA to treat hepatocellular carcinoma,International Journal of Pharmaceutics,2019,572:118769

◆Zhao, Pengxuan; Li, Minsi; Chen, Yan; He, Chuanchuan; Zhang, Xiaojuan; Fan, Ting; Yang, Tan; Lu, Yao; Lee, Robert J; Ma, Xiang;Luo, Jun*; Xiang, Guangya*,Selenium-doped calcium carbonate nanoparticles loaded with cisplatin enhance efficiency and reduce side effects,International Journal of Pharmaceutics,2019,570:118638

◆He, Chuanchuan#;Zhang, Xiaojuan# ;Yan, Ruicong;Zhao, Pengxuan;Chen, Yan; Li, Minsi;Chen, Chen;Fan, Ting; Lu, Yao; Wang, Chen; Wu, Fan;Lee, Robert J.*; Yang, Tan*; Xiang, Guangya*,Enhancement of cisplatin efficacy by lipid-CaO2nanocarrier-mediated comprehensive modulation of the tumor microenvironment,Biomaterials Science,2019,7(10): 4260-4272

◆Khan, Muhammad Waseem ; Zhao, Pengxuan; Khan, Asifullah; Raza, Faisal ; Raza, Shahid Masood ; Sarfraz, Muhammad ; Chen, Yan ; Li, Minsi ; Yang, Tan;Ma, Xiang* ; Xiang, Guangya*,Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity,International Journal of Nanomedicine,2019, 14:3753-3771;

◆Li, Weijie ;Yan, Ruicong ; Liu, Yong;He, Chuanchuan;Zhang, Xiaojuan;Lu, Yao; Khan, Muhammad Waseem;Xu, Chuanrui ;Yang, Tan* ; Xiang, Guangya*,Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo,Drug Delivery,2019, 26(1): 794-802;

◆Gai, Yongkang ; Sun, Lingyi ; Lan, Xiaoli ;Zeng, Dexing* ; Xiang, Guangya*; Ma, Xiang*, Synthesis and Evaluation of New Bifunctional Chelators with Phosphonic Acid Arms for Gallium-68 Based PET Imaging in Melanoma,Bioconjugate Chemistry,2018,29(10): 3483-3494

◆Yang, Tan ; Chen, Yuyuan ; Zhao, Pengxuan ; Xue, Huiying ; You, Jia ; Li, Bin ; Liu, Yong ; He, Chuanchuan; Zhang, Xiaojuan ; Fan, Lingling;Lee, Robert J.; Li, Lei ; Ma, Xiang ;Xu, Chuanrui*; Xiang, Guangya*, Enhancing the therapeutic effect via elimination of hepatocellular carcinoma stem cells using Bmi1 siRNA delivered by cationic cisplatin nanocapsules,Nanomedicine-Nanotechnology Biology and Medicine,2018,14(7): 2009-2021

◆Sarfraz, Muhammad ; Afzal, Attia ; Yang, Tan ; Gai, Yongkang; Raza, Shahid Masood ; Khan, Muhammad Waseem ; Cheng, Yao ;Ma, Xiang* ; Xiang, Guangya*,Development of Dual Drug Loaded Nanosized Liposomal Formulation by A Reengineered Ethanolic Injection Method and Its Pre-Clinical Pharmacokinetic Studies,Pharmaceutics, 2018,10:3

◆Lu, Yao ; Yang, Yannan ; Gu, Zhengying ; Zhang, Jun ; Song, Hao ;Xiang, Guangya* ; Yu, Chengzhong*, Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy,Biomaterials,2018,175: 82-92

◆Zhao, Pengxuan; Li, Minsi; Wang, Yao; Chen, Yan; He, Chuanchuan; Zhang, Xiaojuan; Yang, Tan; Lu, Yao; You, Jia;Lee, Robert J*; Xiang, Guangya*Enhancing anti-tumor efficiency in hepatocellular carcinoma through the autophagy inhibition by miR-375/sorafenib in lipid-coated calcium carbonate nanoparticles.,Acta Biomaterialia,2018,72:248-255

◆Cheng, Yao; Zhao, Pengxuan; Wu, Shuangping; Yang, Tan; Chen, Yan; Zhang, Xiaojuan; He, Chuanchuan; Zheng, Chao; Li, Kelin;Ma, Xiang*; Xiang, Guangya*,Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma,International Journal of Pharmaceutics,2018,545(1-2):261-273

◆Chen, Y; Cheng, Y; Zhao, PX; Zhang, SS; Li, MS; He, CC; Zhang, XJ; Yang, T; Yan, RC; Ye, P;Ma, X*; Xiang, GY*,Co-delivery of doxorubicin and imatinib by pH sensitive cleavable PEGylated nanoliposomes with folate-mediated targeting to overcome multidrug resistance,International Journal of Pharmaceutics,2018,542(1-2):266-279

◆Pengxuan Zhao#, Shuangping Wu, Yao Cheng, Jia You, Yan Chen, Minsi Li, Chuanchuan He, Xiaojuan Zhang, TanYang, Yao Lu, Robert J. Lee,Xingxing He*, Guangya Xiang*, MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma,Nanomedicine: Nanotechnology, Biology, and Medicine,2017,13(8):2507-2516.

◆Yannan Yang#, Yao Lu#, Prasanna Lakshmi Abbaraju, Jun Zhang, Min Zhang,Guangya Xiang,* andChengzhong Yu*,Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy,Angew. Chem. Int. Ed., 2017, 56:8446-8450

◆Muhammad Sarfraz#, Attia Afzal1#, Shahid Masood Raza, Sajid Bashir, Asadullah Madni, Muhammad Waseem Khan,Xiang Ma*,Guangya Xiang*,Liposomal co-delivered oleanolic acid attenuates doxorubicin induced multi-organ toxicity in hepatocellular carcinoma,Oncotarget,2017,8(29):47136-47153

◆Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min1, Weiguang Sun,Lixia Chen*, Guangya Xiang* and Hua Li*,Benserazide, a dopadecarboxylase inhibitor,suppresses tumor growth by targeting hexokinase,Journal of Experimental & Clinic Cancer Research, 2017,36:58

◆Zhongping Hu, Shasha Zhang, Weicheng Zhou,Xiang Ma*, Guangya Xiang*,Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ Inhibitors,Bioorganic & Medicinal Chemistry Letters,2017,27:1854-1858

◆Tan Yang#,Ling Xu#,Bin Li,Weijie Li,Xiang Ma,Lingling Fan,Robert J Lee,Chuanrui Xu*Guangya Xiang*,Antitumor activity of a folate receptor-targeted immunoglobulin G-doxorubicin conjugate,Internatioal Journal of Nanomedicine,2017,12:2505-2515

◆Yongkang Gai#, Lingyi Sun#, Wenqi Hui, Qin Ouyang, Carolyn J. Anderson,Guangya Xiang*, Xiang Ma*, and Dexing Zeng*,New Bifunctional Chelator p‑SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging,Inorganic Chemistry,2016,55(14):6892-6901(IF=4.82)

◆Yao Lu, Yuhua Wang, Lei Miao, Matthew Haynes,Guangya Xiang*, Leaf Huang*, Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approach,Cancer Letters,2016,379(1):32–38(IF=5.992)

◆Yongkang Gai,Guangya Xiang, Xiang Ma, Wenqi Hui, Qin Ouyang, Lingyi Sun, Jiule Ding, Jing Sheng, and Dexing Zeng*,Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes,Bioconjugate Chemistry,2016,27:515-520(IF=4.513)

◆ Lu, Yao; Miao, Lei; Wang, Yuhua; Xu, Zhenghong; Zhao, Yi; Shen, Youqing;Xiang, Guangya*; Huang, Leaf*,Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model,Molecular Therapy,2016,24(2):364-374(IF=6.938)

◆ Yang, Tan; Zhao, Pengxuan; Rong, Zhao; Li, Bin; Xue, Huiying; You, Jia; He, Chuanchuan; Li, Weijie; He, Xingxing; Lee, Robert J;Ma, Xiang*;Guangya Xiang*,Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375,Theranostics,2016,6(1):142-154(IF=8.854)

联系方式

通信方式:武汉市金沙赌城官方网站同济医学院金沙赌城,430030

eMail:gyxiang1968@hotmail.com,youjti@mails.tjmu.edu.cn

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